Arylation of Aldehyde Homoenolates with Aryl Bromides

作者:Cheng Kevin; Walsh Patrick J*
来源:Organic Letters, 2013, 15(9): 2298-2301.
DOI:10.1021/ol4008876

摘要

A mild palladium catalyzed coupling of reactive aldehyde homoenolates with aryl bromides is described. Aldehyde homoenolates are generated by ring opening of cyclopropanols via a C-C cleavage step. The coupling generates aldehyde products at room temperature in 59-93% yield.

  • 出版日期2013-5-3