A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia

作者：Li Xin; Li Juan; Hu Yanjie; Xie Wei; Du Wen; Liu Wei; Li Xiaoqing; Chen Xiangjun; Li Hongrui; Wang Junfeng; Zhang Lannan; Huang Shiang

来源：Leukemia Research, 2012, 36(6): 720-726.

DOI：10.1016/j.leukres.2011.12.016

• Acute lymphoblastic leukemia
• Additional cytogenetic abnormalities
• Chromosomal abnormalities
• Cytogenetic abnormalities
• Cytogenetics
• Molecular cytogenetics

Cytogenetics and molecular cytogenetics of 1466 Chinese patients with de novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1; 19), +8, 12q-, +21, +22 and high hyperdiploidy with 51-65 chromosomes, and lower incidences of t(9; 22) and -5/5q- than adult ones (all p < 0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients.

• 出版日期2012-6
• 单位华中科技大学