Antimicrobial Potential of Benzamides and Derived Nanosystems for Controlling in vitro Biofilm Development on Medical Devices

作者：Limban Carmen; Grumezescu Alexandru Mihai; Chirea Mariana^*; Matei Lilia; Chifiriuc Mariana Carmen

来源：Current Organic Chemistry, 2013, 17(2): 162-175.

DOI：10.2174/1385272811317020013

• Benzamides
• Thiourea derivatives
• Magnetic nanoparticles
• Anti-biofilm properties
• Quorum sensing inhibitors

The aim of this paper is to review the antimicrobial activity of thiourea derivatives against planktonic and adherent bacterial and fungal strains, as well as to show how nanotechnology could improve the intrinsic antimicrobial activity of the novel substances, by obtaining biocompatible nanocomposites based on magnetite nanoparticles and newly synthesized 2-((4-ethylphenoxy)methyl)-N-(alkylphenylcarbamothioyl) benzamides, which proved increased resistance to microbial colonization or inhibited the development of already existent biofilms, revealing a great potential for biomedical applications.

• 出版日期2013-1