Mukaiyama reagent/NaNO2/wet SiO2 as a mild and heterogeneous reagent system for the N-nitrosation of amines and preparation of azides from hydrazines

作者：Azadi Roya^*; Kolivand Khatereh

来源：Tetrahedron Letters, 2015, 56(41): 5613-5615.

DOI：10.1016/j.tetlet.2015.08.057

• Secondary amines
• Tertiary amines
• Mukaiyama reagent
• N-nitrosation
• N-Nitrosamines
• Azides

The combination of the Mukaiyama reagent and sodium nitrite in the presence of wet SiO2 was found to be an effective system for the conversion of amines into N-nitrosamines and hydrazines into azides. The heterogeneous reaction proceeded in good to excellent yields and possesses advantages such as the use of non-hazardous reagents, and simple reaction work-up.

• 出版日期2015-10-7