Activity-mediated shift in reversal potential. of GABA-ergic synaptic currents in immature neurons

作者：Ouardouz M; Sastry BR^*

来源：Developmental Brain Research, 2005, 160(1): 78-84.

DOI：10.1016/j.devbrainres.2005.09.001

• GABA
• reversal potential
• deep cerebellar nucleus
• inhibitory postsynaptic current
• K+-Cl- co-transporter

gamma-Aminobutyric acid (GABA), which is inhibitory in the adult central nervous system, can be excitatory in the developing brain. The change from excitatory to inhibitory action of GABA during development is caused by a negative shift in its reversal potential. Here, we report a presynaptic activity-mediated negative shift in the reversal potential of the GABA-mediated synaptic currents in immature deep cerebellar nuclei neurons. This shift appears to be due to an increased expression and activation of the K+-Cl- co-transporter type 2 (KCC-2) through the activation of protein kinase A, protein synthesis and activation of protein phosphatases. Thus, maturation of the GABA response may rely on an activity-dependent up-regulation of KCC-2.

• 出版日期2005-11-7