A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy

作者：Yi, Yi; Wang, Huijing; Wang, Xuewei; Liu, Qiaoling^*; Ye, Mao^*; Tan, Weihong

来源：ACS Applied Materials & Interfaces, 2017, 9(7): 5847-5854.

DOI：10.1021/acsami.6b15414

• multimodal therapy
• drug release
• photothermal therapy
• photodynamic therapy
• gold nanorod
• aptamer

Multifunctional synergistic therapy holds promise in biomedical studies and clinical practice. However, strategies aimed at easily integrating the components of such multimodal therapies are needed. Therefore, we herein report a smart drug release nanosystem able to perform photodynamic therapy, photothermal therapy and chemotherapy in a photocontrollable manner. Doxorubicin (DOX), a chemotherapy drug, and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4yl) porphyrin (TMPyP4), a photosensitizer, were physically intercalated into a DNA assembly immobilized on gold nanorods. The drugs were efficiently delivered to target cells and released under light irradiation, resulting in a synergism that combined phototherapy and chemotherapy treatment. This smart, photocontrollable drug release nanosystem promises precisely controlled drug release for multifunctional synergistic cancer therapy.

• 出版日期2017-2-22
• 单位湖南大学