Detection of a Novel gyrB Mutation Associated With Fluoroquinolone-Nonsusceptible Salmonella enterica serovar Typhimurium Isolated From a Bloodstream Infection in Ghana

作者：Al Emran Hassan M; Heisig Anke; Dekker Denise; Adu Sarkodie Yaw; Espinoza Ligia Maria Cruz; Panzner Ursula; von Kalckreuth Vera; Marks Florian; Park Se Eun; Sarpong Nimako; May Juergen; Heisig Peter^*

来源：Clinical Infectious Diseases, 2016, 62(suppl 1): S47-S49.

DOI：10.1093/cid/civ790

• fluoroquinolone
• resistance
• gyrB
• Typhimurium

A multidrug-resistant Salmonella enterica serovar Typhimurium with reduced susceptibility to ciprofloxacin was isolated from the blood of a hospitalized child in Ghana. DNA sequencing identified a novel gyrB mutation at codon 466 (Glu466Asp). An increase in fluoroquinolone susceptibility after the introduction of a wild-type gyrB(+) allele demonstrated that the gyrB466 mutation had a direct effect on fluoroquinolone susceptibility.

• 出版日期2016-3-15