Clinical Evaluation of an Unsintered Hydroxyapatite/Poly-L-Lactide Osteoconductive Composite Device for the Internal Fixation of Maxillofacial Fractures

作者：Sukegawa Shintaro^*; Kanno Takahiro; Katase Naoki; Shibata Akane; Takahashi Yuka; Furuki Yoshihiko

来源：Journal of Craniofacial Surgery, 2016, 27(6): 1391-1397.

DOI：10.1097/SCS.0000000000002828

• Maxillofacial fractures
• osteoconductive bioactivity
• resorbable plate
• unsintered hydroxyapatite
• poly-l-lactide composite plate

Introduction:OSTEOTRANS MX (Takiron Co, Ltd, Osaka, Japan) is a resorbable osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its osteoconductive capacity has been documented. The authors here report their clinical experience using OSTEOTRANS MX.Methods:The authors treated 35 patients (19 men, 16 women; age, 14-88 years; meanstandard deviation, 38.419.9 years) with maxillofacial fractures. The authors used standard surgery to stabilize fractures in all patients, fitting resorbable plates (thickness, 1.0 or 1.4mm) and screws (diameter, 2mm) according to Arbeitsgemeinschaft fur Osteosynthesefragen/Association (AO) for the Study of Internal Fixation guidelines.Results:All patients eventually achieved satisfactory healing with favorable restoration of form and function without foreign body reaction. Complications occurred in 3 patientsplate exposure in 2 and discomfort in 1. However, fracture sites healed in all patients. Scanning electron microscopy revealed that the devices bonded directly to the bone without interposition of nonmineralized tissue.Conclusion:OSTEOTRANS MX is a useful material with few complications. Its osteoconductive bioactivity is advantageous for the early functional improvement of maxillofacial fractures.

• 出版日期2016-9