Determinants of survival in HIV patients receiving antiretroviral therapy in Goma, Democratic Republic of Congo

作者：Akilimali P Z^*; Mutombo P B; Kayembe P K; Kaba D K; Mapatano M A

来源：Revue d Epidemiologie et de Sante Publique, 2014, 62(3): 201-206.

DOI：10.1016/j.respe.2014.03.004

• Survival analysis
• Antiretroviral therapy
• HIV patient
• DRC

Background. - The study aimed to identify factors associated with the survival of patients receiving antiretroviral therapy.
Methods. - A historic cohort of HIV patients from two major hospitals in Goma (Democratic Republic of Congo) was followed from 2004 to 2012. The Kaplan-Meier method was used to describe the probability of survival as a function of time since inclusion into the cohort. The log-rank test was used to compare survival curves based on determinants. The Cox regression model identified the determinants of survival since treatment induction.
Results. - The median follow-up time was 3.56 years (IQR = 2.22-5.39). The mortality rate was 40 deaths per 1000 person-years. Male gender (RR: 2.56; 95% CI 1.66-4.83), advanced clinical stage (RR: 2.12; 95% CI 1.15-3.90), low CD4 count (CD4 < 50) (RR: 2.05; 95% CI : 1.22-3.45), anemia (RR: 3.95; 95% CI 2.60-6.01), chemoprophylaxis with cotrimoxazole (RR: 4.29, 95% CI 2.69-6.86) and period of treatment initiation (2010-2011) (RR: 3.34; 95% CI 1.24-8.98) were statistically associated with short survival.
Conclusion. - Initiation of treatment at an early stage of the disease with use of less toxic molecules and an increased surveillance especially of male patients are recommended to reduce mortality.

• 出版日期2014-6