Distribution patterns of cannabinoid CB1 receptors in the hippocampus of APP(swe)/PS1(Delta E9) double transgenic mice

作者：Kalifa Sara; Polston Eva K; Allard Joanne S; Manaye Kebreten F^*

来源：Brain Research, 2011, 1376: 94-100.

DOI：10.1016/j.brainres.2010.12.061

• Alzheimer's disease
• Inflammation
• Astrocytes
• iNOS
• TNF alpha

Cannabinoids have neuroprotective effects that are exerted primarily through cannabinoid CB1 receptors in the brain. This study characterized CB1 receptor distribution in the double transgenic (dtg) APP(swe)/PS1(Delta E9) mouse model for Alzheimer's disease. Immunohistochemical labeling of CB1 protein in non-transgenic mice revealed that CB1 was highly expressed in the hippocampus, with the greatest density of CB1 protein observed in the combined hippocampal subregions CA2 and CA3 (CA2/3). CB1 immunoreactivity in the CA1 and CA2/3 hippocampal regions was significantly decreased in the dtg APP(swe)/PS1(Delta E9) mice compared to non-transgenic littermates. Reduced CB1 expression in dtg APP(swe)/PS1(Delta E9) mice was associated with astroglial proliferation and elevated expression of the cytokines inducible nitric oxide synthase and tumor necrosis factor alpha. This finding suggests an anti-inflammatory effect of cannabinoids that is mediated by CB1 receptor, particularly in the CA2/3 region of the hippocampus. Furthermore, the study suggests a decreased CBI receptor expression may result in diminished anti-inflammatory processes, exacerbating the neuropathology associated with Alzheimer's disease.

• 出版日期2011-2-28