ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group

作者：Linabery Amy M^*; Blommer Crystal N; Spector Logan G; Davies Stella M; Robison Leslie L; Ross Julie A

来源：Leukemia Research, 2013, 37(8): 936-942.

DOI：10.1016/j.leukres.2013.04.022

• Acute lymphoblastic leukemia
• Children
• Genetic susceptibility
• Gene-environment interaction

Interactions between common germline variants in ARID5B and IKZF1 and other known childhood acute lymphoblastic leukemia (ALL) risk factors were queried using biospecimens and data from 770 ALL cases and 384 controls. Casecontrol comparisons revealed dose-dependent associations between ARID5B rs10821936, ARID5B rs10994982, and IKZF1 rs11978267 and childhood ALL overall, and B lineage and B lineage hyperdiploid ALL examined separately (all allelic odds ratios >= 1.33, P-trend <= 0.001). No heterogeneity was observed between ORs for males and females (all P-interaction >= 0.48). Likewise, no significant genotype-birth weight interactions were detected (all P-interaction >= 0.12) among cases. These results indicate similar ALL risk across strata of known risk factors.

• 出版日期2013-8