摘要

The penetration of ampicillin molecule into the beta-cyclodextrin cavity in aqueous solution is studied by (1) H NMR, 2D COSY and ROESY spectroscopy. Obtained data suggest that the phenyl moiety of ampicillin is included inside the hydrophobic cavity of beta-cyclodextrin molecule in the solution, and the mode and depth of this inclusion is confirmed on the basis of 2D ROESY spectral data.

  • 出版日期2010-10