Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb

作者：Rivera Oscar E; Varayoud Jorgelina; Rodriguez Horacio A; Munoz de Toro Monica; Luque Enrique H^*

来源：Reproductive Toxicology, 2011, 32(3): 304-312.

DOI：10.1016/j.reprotox.2011.06.118

• Ovarian follicular dynamics in lambs
• Bisphenol A
• Diethylstilbestrol
• Sheep fertility

We hypothesized that neonatal xenoestrogen exposure affects the ovarian follicular dynamics in lambs. Female lambs were exposed from postnatal day (PND) 1-14 to low doses of diethylstilbestrol (DES) or bisphenol A (BPA). At PND 30, the follicular dynamics and ovarian biomarkers (ER alpha, ER beta, AR, Ki67, p27) were evaluated. Lambs exposed to DES or BPA showed a decline in the stock of primordial follicles with stimulation of follicular development. BPA reduced ovarian weight and increased the number of multioocyte follicles. BPA promoted proliferation of granulosa/theca cells in antral follicles, and increased both the number of antral atretic follicles and p27 expression. Neonatal exposure to BPA or DES reduced the primordial follicle pool by stimulating their initial recruitment and subsequent follicle development until antral stage. In prepubertal lambs, the accelerated folliculogenesis resulted in increased incidence of atretic follicles. These alterations may affect the ovarian function in the adult.

• 出版日期2011-11