mTOR as a multifunctional therapeutic target in HIV infection

作者：Nicoletti Ferdinando^*; Fagone Paolo; Meroni PierLuigi; McCubrey James; Bendtzen Klaus

来源：Drug Discovery Today, 2011, 16(15-16): 715-721.

DOI：10.1016/j.drudis.2011.05.008

Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4(+)-T-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies.

• 出版日期2011-8