A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

作者：Aribi Fallia; Schmitt Etienne; Panossian Armen; Vors Jean Pierre; Pazenok Sergiy; Leroux Frederic R

来源：Organic Chemistry Frontiers, 2016, 3(11): 1392-1415.

DOI：10.1039/c6qo00319b

The present work describes the unprecedented use of Fluoroalkyl Amino Reagents (FARs) to afford 2,4-bis(fluoroalkyl)-substituted quinoline derivatives in two steps under mild reaction conditions, in good yields and with a very good regioselectivity.

• 出版日期2016