Biodegradable therapeutic MOFs for the delivery of bioactive molecules

作者:Miller Stuart R; Heurtaux Daniela; Baati Tarek; Horcajada Patricia; Greneche Jean Marc; Serre Christian*
来源:Chemical communications, 2010, 46(25): 4526-4528.
DOI:10.1039/c001181a

摘要

A new metal organic framework (MOF) built up from non-toxic iron and the therapeutically active linker nicotinic acid, with pellagra-curative, vasodilating, and antilipemic properties, has been isolated and characterised via single crystal methods. The release of the therapeutic agent, which is a constituent of the framework, is achieved through the degradation of the hybrid phase, under simulated physiological conditions, allowing for the delivery of the bioactive molecule.

  • 出版日期2010