A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols

作者：Salomon Pierre^*; Zard Samir Z

来源：Organic Letters, 2014, 16(11): 2926-2929.

DOI：10.1021/ol501063a

The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)-indolines, -indoles, and -naphthols.

• 出版日期2014-6-6