科研之友
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摘要
An environmentally benign protocol for the iodination of imidazoheterocycles has been developed through sp(2) C-H bond functionalization with molecular iodine in water at room temperature. The reaction is catalyzed by an imidazole-based zwitterion-type molten salt. A library of iodo-substituted imidazo[1,2-a] pyridines with broad functionality have been synthesized. This methodology is also applicable to imidazo[2,1-b] thiazole and imidazole scaffolds.
- 出版日期2016-11
