A modular and organocatalytic approach to gamma-butyrolactone autoregulators from Streptomycetes

作者:Elsner Petteri; Jiang Hao; Nielsen Johanne B; Pasi Filippo; Jorgensen Karl Anker*
来源:Chemical communications, 2008, (44): 5827-5829.
DOI:10.1039/b812698d

摘要

A general synthesis of optically active gamma-butyrolactone auto-regulators is developed by a two-step sequence to assemble 2,3-trans-disubstituted butyrolactones in high yields and enantio-selectivities; the scope of this reaction was elaborated by setting up a library of alkyl-substituted butyrolactones and the synthesis of the autoregulators IM-2 and VB-D.

  • 出版日期2008