Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population

作者：Gao, Xiaoyan; Ma, Fei; Hao, Hu; Dai, Yiheng; Liu, Weidong; Xiao, Xin^*; Gao, Pingmin^*; Li, Sitao^*

来源：Pediatrics and Neonatology, 2019, 60(2): 129-134.

DOI：10.1016/j.pedneo.2018.07.002

• necrotizing enterocolitis
• preterm infants
• single-nucleotide polymorphism
• VEGFA

Background: To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. @@@ Material and methods: Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay. @@@ Results: The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC. @@@ Conclusion: Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future.

• 出版日期2019-4
• 单位中山大学; 南方医科大学