Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Obesity in Chinese Han Male College Students

作者：Zhou, Qiong; Zhu, Xiao-Juan; Li, Jiang-Hua^*

来源：Biomed Research International, 2017, 2017: 2984826.

DOI：10.1155/2017/2984826

• RS694539 VARIANT
• NNMT
• FAT
• MICROBIOTA

Some reports have shown that nicotinamide N-methyltransferase (NNMT) is associated with the body mass index (BMI) and energy metabolism. Herewe explored the association between NNMT gene polymorphisms and obesity. Thesubjects were recruited from male Chinese Han college student. 289 of them (19 <= body fat percentage (BF%)) were selected as the high body fat group (HBFG), 494 of them (3 <= BF% < 13.5) were selected as the low body fat group (LBFG), and then a case-control study (fat versus thin) was carried out to explore the association between the NNMT gene polymorphism and the body composition using tagSNPs method. A tag SNP (rs10891644) in NNMT gene was found significantly associated with the body composition (p < 0.0026). At this locus, the BF% for the genotype GT, TT, and GG were 14.56 +/- 8.35, 13.47 +/- 8.11, and 12.42 +/- 7.50, respectively, and the differences between the GT and the GG + TT were highly significant (p < 0.01); the ORadjusted value of the GT versus (GG + TT) was 1.716 P-adjusted = 0.002, 95% CI = 1.240-2.235). There fore, the variation of the tag SNP, rs10891644, is significantly associated with obesity and the GT carriers are the susceptible population.

• 出版日期2017
• 单位江西师范大学