Size-Dependent Active Effect of Cadmium Telluride Quantum Dots on Luminol Potassium Periodate Chemiluminescence System for Levodopa Detection

作者：Wang, Jianbo; Cui, Lijuan; Han, Suqin^*; Hao, Fang

来源：Applied Spectroscopy, 2015, 69(6): 699-704.

DOI：10.1366/14-07632

• Cadmium telluride
• CdTe
• Quantum dots
• Chemiluminescence
• Levodopa
• Luminol
• Pharmaceuticals

It was found that cadmium telluride (CdTe) quantum dots (QDs) with different sizes can have a great sensitizing effect on chemiluminescence (CL) emission from luminol-potassium periodate (KIO4) system. Levodopa, a widely prescribed drug in the treatment of Parkinson's disease, could inhibit luminol-KIO4-CdTe QDs CL reaction in alkaline solution. The inhibited CL intensity was proportional to the concentration of levodopa in the range from 8.0 nM to 10.0 mu M. The detection limit was 3.8 nM. This method has been successfully applied to determine levodopa in pharmaceutical preparation and human urine and plasma samples with recoveries of 94.1-105.4%. This was the first work for inhibition effect determination of levodopa using a QD-based CL method.

• 出版日期2015-6
• 单位山西师范大学