Dynamics of methicillin-resistant Staphylococcus aureus and methicillin-susceptible Staphylococcus aureus carriage in pig farmers: a prospective cohort study

作者：van Cleef B A G L^*; van Benthem B H B; Verkade E J M; van Rijen M; Kluytmans van den Bergh M F Q; Schouls L M; Duim B; Wagenaar J A; Graveland H; Bos M E H; Heederik D; Kluytmans J A J W

来源：Clinical Microbiology and Infection, 2014, 20(10): O764-O771.

DOI：10.1111/1469-0691.12582

• Dynamics of carriage
• epidemiology
• livestock
• methicillin-resistant Staphylococcus aureus
• methicillin-susceptible Staphylococcus aureus
• MRSA
• MSSA
• pigs
• ST398
• the Netherlands

Our purpose was to determine the dynamics of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) carriage and its determinants in persons working at pig farms, in order to identify targets for interventions. This prospective cohort study surveyed 49 pig farms in the Netherlands on six sampling dates in 1year (2010-11). Nasal and oropharyngeal swabs were collected, as well as environmental surface samples from stables and house. Of 110 pig farmers, 38% were persistent MRSA nasal carriers. The average cross-sectional MRSA prevalence was 63%. Methicillin-susceptible S.aureus (MSSA) nasal carriage was associated with fewer MRSA acquisitions (prevalence rate (PR)=0.47, p0.02). In multivariate analysis, an age of 40-49years (PR=2.13, p0.01), a working week of 40h (PR=1.89, p0.01), giving birth assistance to sows (PR=2.26, p0.03), removing manure of finisher pigs (PR=0.48, p0.02), and wearing a facemask (PR=0.13, p0.02) were significantly related with persistent MRSA nasal carriage. A higher MRSA exposure in stables was associated with MRSA in pig farmers (p<0.0001). This study describes a very high prevalence of LA-MRSA carriage in pig farmers, reflecting extensive exposure during work. We identified the possible protective effects of MSSA carriage and of continuously wearing a facemask during work.

• 出版日期2014-10