The Effect of Respiratory and Cardiac Motion in Liver Diffusion Tensor Imaging (DTI)

作者：Wong Oi Lei; Lo Gladys Gloh; Lee Raymond; Li Wing Wa; Chan Po Lung; Yu Siu Ki; Noseworthy Michael D^*

来源：Journal of Computer Assisted Tomography, 2014, 38(3): 352-359.

DOI：10.1097/rct.0000000000000064

• magnetic resonance imaging (MRI)
• diffusion tensor imaging (DTI)
• healthy liver

Objective: To evaluate the effect of respiratory and cardiac motion on diffusion tensor imaging (DTI) metrics in healthy human liver.
Methods: Fifteen healthy subjects, participating in either part of this study, were scanned using a 1.5-T magnetic resonance imaging (MRI) device. Coronal liver DTI (6 diffusion-encoding directions; b, 300 mm(2)/s) during breath holding was compared to free breathing. Cardiac motion effects were evaluated by comparing breath-held DTI scans acquired during both diastole and systole.
Results: Free breathing resulted in a significantly increased mean diffusivity (P < 0.05), lambda(1) (P < 0.01), lambda(2) (P < 0.05), and lambda(3) (P < 0.01) compared to breath holding. During systole significant increases in fractional anisotropy (P < 0.05), mean diffusivity (P < 0.05), and lambda(1) (P < 0.05), compared to systole, were found in the left lobe. The right lobe, which is less affected by cardiac motion, showed no significant change in DTI metrics over the cardiac cycle.
Conclusions: Respiratory and cardiac motion tends to increase liver DTI metrics.

• 出版日期2014-6