科研之友
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摘要
Background: Breast cancer susceptibility gene 1 (BRCA1) expression differentially affects outcome to platinum-and taxane-based chemotherapy. Mediator of DNA damage checkpoint protein 1 (MDC1), p53-binding protein 1 (53BP1), multiple myeloma SET domain (MMSET) and ubiquitin-conjugating enzyme 9 (UBC9) are involved in DNA repair and could modify the BRCA1 predictive model Methods: Mediator of DNA damage checkpoint protein 1, 53BP1, MMSET and UBC9 mRNA were assessed in gastric tumours from patients in whom BRCA1 levels had previously been determined. Results: In vitro chemosensitivity assay, MMSET levels were higher in docetaxel-sensitive samples. In a separate cohort, survival was longer in those with low MMSET (12.3 vs 8.8 months; P -0.04) or UBC9 (12.4 vs 8.8 months; P -0.01) in patients receiving only folinic acid, fluorouracil (5-FU) and oxaliplatin (FOLFOX). Conversely, among patients receiving second-line docetaxel, longer survival was associated with high MMSET (19.1 vs 13.9 months; P = 0.003). Patients with high MMSET and BRCA1 attained a median survival of 36.6 months, compared with 13.9 months for those with high BRCA1 and low MMSET (P -0.003). In the multivariate analyses, low MMSET (hazard ratio (HR), 0.59; P = 0.04) and low UBC9 (HR, 0.52; P = 0.01) levels were markers of longer survival to first-line FOLFOX, whereas palliative surgery (HR, 2.47; P = 0.005), low BRCA1 (HR, 3.17; P = 0.001) and low MMSET (HR, 2.52; P = 0.004) levels were markers of shorter survival to second-line docetaxel. Conclusions: Breast cancer susceptibility gene 1, MMSET and UBC9 can be useful for customising chemotherapy in gastric cancer patients.
- 出版日期2014-5-27
- 单位南京大学
