Evaluation of death pathway genes FAS and FASL polymorphisms in chronic HBV infection

作者：Zamani A G^*; Barlas I O; Durakbasi Dursun G; Ural O; Erdal E; Yildirim M S

来源：International Journal of Immunogenetics, 2013, 40(6): 482-487.

DOI：10.1111/iji.12056

This study was designed to determine the possible asssociation between selected FAS and FASLG polymorphisms and Hepatitis B virus (HBV) infection. FAS-670 G/A, FAS-1377 G/A, FASLG-844 T/C and FASLGIVS2nt-124 A/G polymorphisms were genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). A total of age and sex matched 108 controls and a hundred chronic HBV patients were recruited to conduct a case-control study. FAS-670 polymorphism was associated with chronic HBV infection (P=0.03) FAS-1377 GG, GA and AA genotypes among the cases (90%, 5% and 5%, respectively) were significantly different from those among the controls (68%, 31.5% and 5.6%; P=0.00). FASLG-844 allele distribution was similar between the groups (P=0.17) but TC genotype (67.3%) was frequent in chronic HBV patients, while CC genotype was found significantly higher (29.6%) in controls. No association between FASLGIVS2nt-124 polymorphism and chronic HBV infection could be identified (P=0.55). FAS-670 polymorphism is associated with chronic HBV infection, while FASLGIVS2nt-124 A/G polymorphism is not. The FAS-1377G/A and FASLG-844 T/C genotypes are likely to play a substantial role in HBV infection. Further studies evaluating polymorphisms in other genes related with apoptosis are needed to elucidate the role of genetic variation in HBV infection.

• 出版日期2013-12