Application of 3,3 '-disubstituted xylBINAP derivatives in inter- and intramolecular asymmetric Heck/Mizoroki reactions

作者：Rankic Danica A; Lucciola Daniela; Keay Brian A^*

来源：Tetrahedron Letters, 2010, 51(43): 5724-5727.

DOI：10.1016/j.tetlet.2010.08.078

• Heck/Mizoroki reactions
• Polyene cyclization
• BINAP
• 3,3 '-Disubstitution
• 3,5-Dialkyl meta effect

3,3'-Disubstituted xylBINAP derivatives were applied to inter- and intramolecular asymmetric Heck/Mizoroki reactions. The results from these reactions were compared to those obtained with (R)-xylBINAP, (S)-BINAP and 3,3'-disubstituted BINAP derivatives. Catalysts derived from 3,3'-disubstituted xylBINAP ligands were found to be most effective in the arylation of 2,3-dihydrofuran in terms of reaction times, conversions, and product enantioselectivity.

• 出版日期2010-10-27