An environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines

作者：Rimaz Mehdi^*; Aali Farkhondeh

来源：Chinese Journal of Catalysis, 2016, 37(4): 517-525.

DOI：10.1016/S1872-2067(15)61060-9

• 1,4-Diazabicyclo[2.2.2]octane (DABCO)
• Propiophenone
• Arylglyoxalmonohydrate
• Pyridazine

This report describes a new three-component strategy for the regioselective synthesis of a series of tri-substituted pyridazines via a 1,4-diazabicyclo[2.2.2]octane (DABCO)-catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one-pot route toward a diverse set of 3,6-diary1-4-methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base-organocatalyst, and affords good to excellent yields of products.

• 出版日期2016-4