科研之友
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摘要
Study Objectives: An improved animal model of obstructive sleep apnea (OSA) is needed for the development of effective pharmacotherapies. In humans, flexion of the neck and a supine position, two main pathogenic factors during human sleep, are associated with substantially greater OSA severity. We postulated that these two factors might generate OSA in animals. Design: We developed a restraining device for conditioning to investigate the effect of the combination of 2 body positions-prone (P) or supine (S)-and 2 head positions-with the neck flexed at right angles to the body (90 degrees) or in extension in line with the body (180 degrees)-during sleep in 6 cats. Polysomnography was performed twice on each cat in each of the 4 sleeping positions-P180, S180, P90, or S90. The effect of continuous positive airway pressure (CPAP) treatment was then investigated in 2 cats under the most pathogenic condition. Setting: NA. Patients or Participants: NA. Interventions: NA. Measurements and Results: Positions P180 and, S90 resulted, respectively, in the lowest and highest apnea-hypopnea index (AHI) (3 +/- 1 vs 25 +/- 2, P < 0.001), while P90 (18 +/- 3, P < 0.001) and S180 (13 +/- 5, P < 0.01) gave intermediate values. In position S90, an increase in slow wave sleep stage 1 (28% +/- 3% vs 22% +/- 3%, P < 0.05) and a decrease in REM sleep (10% +/- 2% vs 18% +/- 2%, P < 0.001) were also observed. CPAP resulted in a reduction in the AHI (8 +/- 1 vs 27 +/- 3, P < 0.01), with the added benefit of sleep consolidation. Conclusion: By mimicking human pathogenic sleep conditions, we have developed a new reversible animal model of OSA.
- 出版日期2011-4-1
