Asymmetric Dehydrative C-, N-, and O-Allylation Using Naph-diPIM-dioxo-i-Pr-CpRu/p-TsOH Combined Catalyst

作者：Miyata Kengo; Kitamura Masato^*

来源：Synthesis, 2012, 44(14): 2138-2146.

DOI：10.1055/s-0031-1290301

• dehydrative allylation
• asymmetric catalysis
• cyclopentadienyl ruthenium
• chiral bidentate sp(2)N ligand

(S,S)- or (R,R)-Naph-diPIM-dioxo-i-Pr-CpRu(II) complex with a Bronsted acid catalyzes dehydrative intermolecular C-allylation with high enantio- and regioselectivity. The new soft Ru/hard H+ combined catalyst can also be used for intramolecular C-, N-, and O-allylations, giving nearly enantiomerically pure alpha-alkenyl-substituted cyclic compounds. As water is only the co-product, the synthetic process can be readily scaled up.

• 出版日期2012-7