Adults with Down syndrome have reduced cardiac response after light exercise testing

作者：Vis J C; De Bruin Bon H A C M; Bouma B J; Huisman S A; Imschoot L; van den Brink K; Mulder B J M^*

来源：Netherlands Heart Journal, 2012, 20(6): 264-269.

DOI：10.1007/s12471-012-0254-1

• Down syndrome
• Cardiac response
• Cardiac index
• Exercise testing
• Echocardiography
• Stroke volume

Physical fitness is reduced in adults with Down syndrome (DS). The present study was conducted to elucidate the exercise response in adults with DS. %26lt;br%26gt;Case controlled before-after trial. %26lt;br%26gt;Residential centre for people with intellectual disabilities. %26lt;br%26gt;96 Adults with DS, 25 non-DS adults with an intellectual disability, 33 controls. %26lt;br%26gt;Echocardiography to exclude heart defects and to measure cardiac index (CI) in the supine position, supine position with raised legs, and following ten knee bends. %26lt;br%26gt;Exercise testing %26lt;br%26gt;At rest, mean CI was not significantly different between persons with DS and controls (2.3 vs. 2.4 l/min/m(2), p = 0.3). However, mean CI after exercise was significantly lower in DS (2.9 vs. 3.7 l/min/m(2), p %26lt; 0.001) and mean CI increase from rest to exercise was more than 50% lower in DS. On the contrary, CI after exercise was similar among controls and non-DS adults with an intellectual disability. Significantly lower stroke volumes in DS were found with insufficient heart rate response. %26lt;br%26gt;CI at rest was similar in adults with DS and controls; however persons with DS have a diminished cardiac response to exercise. Stroke volumes were significantly lower in DS during exercise and a compensated heightened heart rate was absent.

• 出版日期2012-6