Nuclear functions of the HMG proteins

作者：Reeves Raymond^*

来源：Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2010, 1799(1-2): 3-14.

DOI：10.1016/j.bbagrm.2009.09.001

Although the three families of mammalian HIVIG proteins (HMGA, HMGB and HMGN) participate in many of the same nuclear processes, each family plays its own unique role in modulating chromatin structure and regulating genomic function. This review focuses oil the similarities and differences in the mechanisms by which the different HMG families impact chromatin Structure and influence cellular phenotype. The biological implications of having three architectural transcription factor families with complementary, but partially overlapping, nuclear functions are discussed.

• 出版日期2010-2