Neurovascular Control and Cardiac Structure in Amateur Runners with Hypertension

作者：Perlingeiro Patricia De Sa; Azevedo Luciene Ferreira; Gomes Santos Igor Lucas; Bortolotto Luiz Aparecido; Pinto Brandao Rondon Maria Urbana; Negrao Carlos Eduardo; Nagem Janot de Matos Luciana Diniz

来源：Medicine and Science in Sports and Exercise, 2016, 48(1): 26-32.

DOI：10.1249/MSS.0000000000000751

• HYPERTENSION
• BAROREFLEX SENSITIVITY
• ARTERIAL STIFFNESS
• SYMPATHETIC NERVOUS SYSTEM
• ATHLETES

Purpose The neurovascular mechanisms underlying hypertension are minimized by exercise training. However, it is not known whether previously trained individuals with hypertension would have deleterious repercussion of this disease. Our aim was to investigate the neurovascular control and the cardiac structure of athletes with hypertension.
Methods Muscle sympathetic nerve activity (MSNA) (microneurography), baroreflex sensitivity (intravenous infusion of phenylephrine and nitroprusside), arterial stiffness (pulse wave velocity and echotracking), and cardiac structure (echocardiography) were evaluated in 17 runners with hypertension (42 1 yr) and 20 normotensive (43 1 yr) amateur runners.
Results Runners with hypertension had higher MSNA (+24% burst frequency, P = 0.02; +24%, burst incidence, P < 0.01), left ventricular mass (+22%, P < 0.01), septum wall thickness (+9%, P = 0.04), posterior wall thickness (+11%, P = 0.04), and left atrium (+11%, P < 0.001) compared with normotensive runners. Baroreflex control of heart rate was lower in runners with hypertension during increase (P = 0.05) but not during decrease (P = 0.11) of systolic blood pressure when compared with normotensive runners. There was no difference between groups in baroreflex control of MSNA during increase (P = 0.38) and decrease (P = 0.36) of diastolic blood pressure. Pulse wave velocity (P = 0.71) and carotid variables: intima media thickness (P = 0.18), diameter (P = 0.09), and distension (P = 0.79) were similar between groups.
Conclusions Sympathetic overactivity seems to be involved in the underlying mechanisms of hypertension in amateur runners. Alterations in cardiac structure and decreased baroreflex control of heart rate suggest limited protection from exercise training. However, baroreflex control of MSNA and elastic properties of artery are preserved in this population.

• 出版日期2016-1