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摘要
Aims. To compare the prevalence of anosognosia in patients with Alzheimer%26apos;s disease (AD) using two different evaluation methodologies, to analyse the discrepancy between them and to determine the variables associated with this discrepancy. %26lt;br%26gt;Patients and methods. The methodology involved a cross-sectional, observational study conducted in patients with AD. The Anosognosia Questionnaire-Dementia (AQ-D) and the Experimenter Rating Scale (ERS) were administered. Clinical and sociodemographic information was recorded about both the patient and his/her caregiver by means of standardised instruments. Prevalence was determined with each instrument and the degree of agreement between them was then established. A variable called %26apos;agreement/non-agreement%26apos; was created and a logistic regression model was adjusted to determine the variables associated to the discrepancy. %26lt;br%26gt;Results. The prevalence of anosognosia in the mild cases was 13.6% (95% confidence interval, 95% Cl = 5.5-21.7) and 17.3% (95% Cl = 8.4-26.1), and 44.2% (95% Cl = 28.2-60.2) and 55.8% (95% Cl = 38.8-71.8) in the moderate cases, according to the ERS and the AQ-D, respectively. The degree of agreement between the two measurements yielded a kappa-value of 0.7. The regression model with the discrepancy between the ERS and the AQ-D as the dependent variable was associated to a lower functional capacity (odds ratio = 0.080; 95% Cl = 0.855-0.997; p = 0.042). %26lt;br%26gt;Conclusions. The data from the study showed an increase in the prevalence of anosognosia linked to the severity and a higher disagreement in its evaluation with two different methods as the degree of the patient%26apos;s functional disability increased.
- 出版日期2012-2-16
