Nano-islands integrated evanescence-based lab-on-a-chip on silica-on-silicon and polydimethylsiloxane hybrid platform for detection of recombinant growth hormone

作者：Ozhikandathil J; Packirisamy M^*

来源：Biomicrofluidics, 2012, 6(4): 046501.

DOI：10.1063/1.4757968

• bioMEMS
• biosensors
• chemical sensors
• finite difference time-domain analysis
• gold
• island structure
• lab-on-a-chip
• microfluidics
• microsensors
• molecular biophysics
• nanostructured materials
• optical sensors
• proteins
• ultraviolet spectra
• visible spectra
• wave propagation

Integration of nano-materials in optical microfluidic devices facilitates the realization of miniaturized analytical systems with enhanced sensing abilities for biological and chemical substances. In this work, a novel method of integration of gold nano-islands in a silica-on-silicon-polydimethylsiloxane microfluidic device is reported. The device works based on the nano-enhanced evanescence technique achieved by interacting the evanescent tail of propagating wave with the gold nano-islands integrated on the core of the waveguide resulting in the modification of the propagating UV-visible spectrum. The biosensing ability of the device is investigated by finite-difference time-domain simulation with a simplified model of the device. The performance of the proposed device is demonstrated for the detection of recombinant growth hormone based on antibody-antigen interaction.

• 出版日期2012-12