Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy

作者：Mei, Fangchao; Zuo, Teng; Zhao, Liang; Shi, Qiao; Xiang, Mingwei; Hong, Yupu; Li, Man; Wang, Weixing^*

来源：Archives of Gynecology and Obstetrics, 2018, 297(4): 933-942.

DOI：10.1007/s00404-018-4668-x

• Acute pancreatitis
• Pregnancy
• Renal injury
• MAPK

The objective of this study was to determine the mechanism of acute renal injury (ARI) in acute necrotizing pancreatitis in late pregnancy (ANPIP). @@@ Pregnant Sprague-Dawley rats in the third trimester were used for this study, and an ANPIP model was induced by injecting 5% sodium taurocholate into the biliary pancreatic duct. The rats were randomly divided into three groups: the normal, sham-operated (SO) and acute necrotizing pancreatitis (ANP) groups. Rats were killed at 3, 6, 12 h after the operation, and blood, pancreatic and renal tissue samples were harvested. Differences were detected in the physiology, pathology and cellular and molecular responses among the different groups. @@@ Serum amylase, lipase, urea and Cr levels were increased in rats with ANPIP. Additionally, expression of phosphorylation p38 and JNK as well as TNF-alpha and NF-kappa B were increased in the renal tissues of rats with ANPIP. The expression of phosphorylation ERK was decreased in the renal tissues of rats with ANPIP. @@@ Mitogen-activated protein kinases may play an important role in renal injury in rat models of ANPIP.

• 出版日期2018-4
• 单位武汉大学