Determination of the upper cut-off values of serum alanine aminotransferase and aspartate aminotransferase in Chinese

作者：Zhang, Peng; Wang, Chun-Yan; Li, Yu-Xiang; Pan, Yu^*; Niu, Jun-Qi; He, Shu-Mei

来源：World Journal of Gastroenterology, 2015, 21(8): 2419-2424.

DOI：10.3748/wjg.v21.i8.2419

• Alanine aminotransferase
• Aspartate aminotransferase
• Upper cut-off value
• Northern Chinese population
• Serum alanine aminotransferase and aspartate aminotransferase

AIM: To determine the upper cut-off values of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a Northern Chinese population. @@@ METHODS: A total of 3769 subjects in Jilin Province Northeast China were stratified to determine the potential factors affecting serum ALT and AST levels. The upper cut-off values of serum ALT and AST in these subjects were determined using receiver operating characteristic analysis and their sensitivity and specificity were evaluated. @@@ RESULTS: Stratification analysis revealed that serum ALT and AST levels were associated with gender, alcohol consumption, serum cholesterol and triglyceride levels, and body mass index. The upper cut-off values of serum ALT and AST were 22.15 U/L and 25.35 U/L for healthy men and 22.40 U/L and 24.25 U/L for healthy women, respectively. The new cut-off values had a higher sensitivity, but a slightly lower specificity than the current standards. @@@ CONCLUSION: Our results indicate that the new upper cut-off values of serum ALT and AST are markedly lower than current standards and may be valuable for the evaluation of liver function.

• 出版日期2015-2-28
• 单位吉林大学