A new route to the versatile synthesis of thiopyrano [2,3-b:6,5-b ']diindoles via 2-(alkylthio)-indole-3-carbaldehydes

作者：Jha Mukund^*; Edmunds Michael; Lund Kate lyn; Ryan Ashley

来源：Tetrahedron Letters, 2014, 55(41): 5691-5694.

DOI：10.1016/j.tetlet.2014.08.100

• Indole
• Heteroaromatic
• Formylation
• Sulfide
• Cyclization

A versatile synthesis of symmetrically and unsymmetrically substituted thiopyrano[2,3-b:6,5-b']diindoles has been developed by the condensation of 2-(alkylthio)-indole-3-carbaldehydes with indoline-2-thiones in the presence of catalytic amount of ethylenediamine diacetate (EDDA). The EDDA mediated condensation leads to a spontaneous cyclization followed by aromatization to form thiopyrano[2,3-b:6,5-b']diindoles in quantitative yields.

• 出版日期2014-10-8