A strategy for generating alkyl radicals from aliphatic esters and lactones via sequential hydrolysis and photoinduced decarboxylation

作者：Saito Hikaru; Kanetake Takayuki; Osaka Kazuyuki; Maeda Kousuke; Morita Toshio; Yoshimi Yasuharu^*

来源：Tetrahedron Letters, 2015, 56(13): 1645-1648.

DOI：10.1016/j.tetlet.2015.02.020

• Generating alkyl radical
• Aliphatic ester and lactone
• Hydrolysis
• Photoinduced decarboxylation
• Radical reaction

Sequential hydrolysis and photoinduced decarboxylation of methyl aliphatic esters lead to efficient generation of alkyl radicals under mild conditions. The generated alkyl radicals react with a variety of reagents to produce addition, reduction, and substitution products. In addition, the new tin and halogen free process for alkyl radical generation is applicable to a variety of aliphatic esters including those of dipeptides, steroids, saccharides, and lactones.

• 出版日期2015-3-25