Genetic architecture of body size in mammals

作者：Kemper Kathryn E^*; Visscher Peter M; Goddard Michael E

来源：Genome Biology, 2012, 13(4): 244.

DOI：10.1186/gb-2012-13-4-244

• Human height
• mutation effects
• mutation-selection balance

Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

• 出版日期2012