Association between adherence to dietary recommendations and high-sensitivity C-reactive protein level in type 1 diabetes

作者：Ahola Aila J; Saraheimo Markku; Freese Riitta; For**lom Carol; Makimattila Sari; Groop Per Henrik^*

来源：Diabetes Research and Clinical Practice, 2017, 126: 122-128.

DOI：10.1016/j.diabres.2017.02.012

• Adherence to dietary
• recommendations
• hs-CRP
• Low-grade inflammation
• Type 1 diabetes

Aims: Inflammation plays an important role in the pathogenesis of cardiovascular diseases. Diet, as a modifiable risk factor, may in turn impact systemic inflammation. We therefore assessed whether adherence to the dietary recommendations is associated with high-sensitivity C-reactive protein (hs-CRP) concentrations in type 1 diabetes.
Methods: Cross-sectional data from 677 FinnDiane study participants (48% men, mean +/- standard deviation age 46 +/- 13 years) were included. Dietary intake was assessed with a self-administered questionnaire. A diet score, with higher values denoting better adherence to the recommendations, was calculated. Serum hs-CRP concentration was measured, and individuals with hs-CRP < 1.0 mg/l, and hs-CRP > 3.0 but < 10.0 mg/l were compared.
Results: Men and women with high hs-CRP had higher BMI, waist circumference, and triglyceride concentration, but lower HDL-cholesterol concentration. Adjusted for BMI, mean diet score was higher in the low hs-CRP group, both in men (10.8 +/- 3.6 vs. 9.9 +/- 3.8, p = 0.023) and women (12.7 +/- 3.4 vs. 11.6 +/- 3.5, p = 0.021). After further adjustments with potential confounding factors, the difference remained significant only in men.
Conclusions: A diet that more closely adheres to the dietary recommendations is associated with lower hs-CRP in men. A prudent diet may help reduce systemic inflammation in type 1 diabetes.

• 出版日期2017-4