New cyclodextrin derivative 6-O-(2-hydroxybutyl)-β-cyclodextrin: preparation and its application in molecular binding and recognition

作者：Sun, Hong Yuan; Bai, Yan; Zhao, Ming Gang; Hao, Ai You^*; Xu, Gui Ying; Shen, Jian; Li, Jian Ye; Sun, Tao; Zhang, Hua Cheng

来源：Carbohydrate Research, 2009, 344(15): 1999-2004.

DOI：10.1016/j.carres.2009.07.010

• 6-O-(2-Hydroxybutyl)-beta-cyclodextrin
• 6-HB-beta-CD
• 1,2-Butylene oxide
• Recognition

A new soluble cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin (6-HB-beta-CD) was prepared. Its molecular binding and recognition ability were investigated with the comparison of p-cyclodextrin (beta-CD), 2-O-(2-hydroxypropyl)-beta-cyclodextrin (2-HP-beta-CD), 6-O-(2-hydroxypropyl)-beta-cyclodextrin (6-HP-beta-CD), and 2-O-(2-hydroxybutyl)-beta-cyclodextrin (2-HB-beta-CD). The relationship between the complex stability constants and the possible structures of inclusion compounds was discussed with the interaction of hosts and guests, including the weak hydrophobic interactions, the size/shape matching, the steric hindrance, and the hydrophilic property.

• 出版日期2009-10-12
• 单位山西师范大学; 山东大学