Association of three SNPs in interleukin-28B with graft hepatic dysfunction after liver transplantation in Chinese Han population

作者：Chen, Jie; Li, Yi; Wang, Lanlan^*; Fu, Yang; Liao, Yun; Zhang, Junlong

来源：Gene, 2012, 508(1): 121-124.

DOI：10.1016/j.gene.2012.07.065

• Graft hepatic dysfunction
• Liver transplantation
• IL-28B
• SNPs

Background: Recurrent graft infection limited the effect of LT, early recognition and prophylaxis of HBV recurrence are very important, and interleukin 28B (IL-28B) gene was reported to be associated with HBV infection. @@@ Aims: To explore the association between IL-28B single-nucleotide polymorphisms (SNPs) and graft re-infection after liver transplantation(LT). @@@ Methods: 21 recipients with hepatitis B virus(HBV) recurrence and 157 recipients without HBV recurrence were included. We studied three SNPs in the promoter region of IL-28B gene at the positions rs12979860, rs12980275 and rs8099917 by HRM analysis (high-resolution melting curve analysis). @@@ Results: Hepatic allograft dysfunction was more likely to be associated with IL-28B SNPs. However, there was no significant difference in the frequencies of IL-28B gene distribution in recipients with or without HBV recurrence. @@@ Conclusion: IL-28B gene polymorphism may be associated with the prognosis of LT recipients but it needs more experiments.

• 出版日期2012-10-15
• 单位四川大学