Diffusion tensor imaging differentiates vascular parkinsonism from parkinsonian syndromes of degenerative origin in elderly subjects

作者：Deverdun Jeremy; de Champfleur Sophie Menjot; Cabello Aguilar Simon; Maury Florence; Molino Francois; Charif Mahmoud; Leboucq Nicolas; Ayrignac Xavier; Labauge Pierre; Bonafe Alain; Castelnovo Giovanni; Le Bars Emmanuelle; Geny Christian; de Champfleur Nicolas Menjot

来源：European Journal of Radiology, 2014, 83(11): 2074-2079.

DOI：10.1016/j.ejrad.2014.07.012

Background and Purpose: The etiologic diagnosis of parkinsonian syndromes is of particular importance when considering syndromes of vascular or degenerative origin. The purpose of this study is to find differences in the white-matter architecture between those two groups in elderly patients.
Materials and Methods: Thirty-five patients were prospectively included (multiple-system atrophy, n= 5; Parkinson's disease, n=15; progressive supranuclear palsy, n=9; vascular parkinsonism, n= 6), with a mean age of 76 years. Patients with multiple-system atrophy, progressive supranuclear palsy and Parkinson's disease were grouped as having parkinsonian syndromes of degenerative origin. Brain MRIs included diffusion tensor imaging. Fractional anisotropy and mean-diffusivity maps were spatially normalized, and group analyses between parkinsonian syndromes of degenerative origin and vascular parkinsonism were performed using a voxel-based approach.
Results: Statistical parametric-mapping analysis of diffusion tensor imaging data showed decreased fractional anisotropy value in internal capsules bilaterally in patients with vascular parkinsonism compared to parkinsonian syndromes of degenerative origin (p = 0.001) and showed a lower mean diffusivity in the white matter of the left superior parietal lobule (p = 0.01).
Fractional anisotropy values were found decreased in the middle cerebellar peduncles in multiplesystem atrophy compared to Parkinson's disease and progressive supranuclear palsy. The mean diffusivity was increased in those regions for these subgroups.
Conclusion: Clinically defined vascular parkinsonism was associated with decreased fractional anisotropy in the deep white matter (internal capsules) compared to parkinsonian syndromes of degenerative origin. These findings are consistent with previously published neuropathological data.

• 出版日期2014-11