A lethal combination for cancer cells: Synthetic lethality screenings for drug discovery

作者：Ferrari Elisa; Lucca Chiara; Foiani Marco^*

来源：European Journal of Cancer, 2010, 46(16): 2889-2895.

DOI：10.1016/j.ejca.2010.07.031

• Synthetic lethality screens
• Cancer
• Saccharomyces cerevisiae
• Drug discovery

In recent years cancer drug discovery has faced the challenging task of integrating the huge amount of information coming from the genomic studies with the need of developing highly selective target based strategies within the context of tumour cells that experience massive genome instability
The combination between genetic and genomic technologies has been extremely useful and has contributed to efficiently transfer certain approaches typical of basic science to drug discover projects An example comes from the synthetic lethal approaches very powerful procedures that employ the rational used by geneticists working on model organisms Applying the synthetic lethality(SL) screenings to anticancer therapy allows exploiting the typical features of tumour cells such as genome instability without changing them as opposed to the conventional anticancer strategies that aim at counteracting the oncogenic signalling pathways
Recent and very encouraging clinical studies clearly show that certain promising anti cancer compounds work through a synthetic lethal mechanism by targeting pathways that are specifically essential for the viability of cancer cells

• 出版日期2010-11