A Facile Total Synthesis of Neurotrophic Metabolite (plus/-)-Neuchromenin

作者：Ferreira Ramos Josierika A; Nagem Tanus J; Taylor Jason G^*

来源：Letters in Organic Chemistry, 2014, 11(3): 194-196.

• Neuchromenin
• sesamol
• fries rearrangement
• Baylis-Hillman Reaction

The synthesis of (+/-)-neuchromenin, a known natural product that induces neurite outgrowth of PC12 cells, is described. The total synthesis involved constructing a chromone ring from sesamol and coupling this intermediate to an aldehyde by a Morita-Baylis-Hillman reaction (MBH). The MBH adduct was cyclized under acidic conditions followed by removal of a methylene group to afford (+/-)-neuchromenin in 9 steps from sesamol.

• 出版日期2014