Nano-TiCl4/SiO2: An efficient heterogeneous solid acid catalyst for the one pot cascade five-component synthesis of densely functionalized tetrahydropyridines

作者：Bamoniri Abdolhamid^*; Mirjalili Bi Bi Fatemeh; Tarazian Reza

来源：Journal of Chemical Sciences, 2015, 127(5): 885-895.

DOI：10.1007/s12039-015-0845-7

• Tetrahydropyridines
• Nano-TiCl4/SiO2
• heterogeneous catalyst
• five-component reaction
• one-pot synthesis

Nano-TiCl4/SiO2 was found to be an inexpensive and efficient heterogeneous solid acid catalyst for the synthesis of one-pot cascade synthesis of highly functionalized asymmetric tetrahydropyridines from the five-component condensation reaction of the para-substituted anilines and aromatic aldehydes with ethyl acetoacetate under thermal conditions. Novel methodology, environmentally benign conditions, clean protocol, easy work-up and high yields are the important advantages of this protocol. The products were characterized using physical and spectroscopic data such as FT-IR, H-1-NMR and in some cases C-13-NMR and CHN analysis.

• 出版日期2015-5