Mild water-promoted selective deacetalisatison of acyclic acetals

作者:Williams D Bradley G*; Cullen Adam; Fourie Alex; Henning Hendrik; Lawton Michelle; Mommsen Wayne; Nangu Portia; Parker Jonathan; Renison Alicia
来源:Green Chemistry, 2010, 12(11): 1919-1921.
DOI:10.1039/c0gc00280a

摘要

Various aliphatic and aromatic dimethyl and diethyl acetals and ketals were found to hydrolyse in essentially quantitative yield when heated to 80 degrees C in neat water or aqueous medium without a catalyst or any other additive, while cyclic acetals were stable under these conditions. Selective deprotection is possible when both types of acetal are present.

  • 出版日期2010