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摘要
A study on pharmacokinetics of ponazuril in piglets was conducted after a single oral dose of 5.0mg/kg b.w. Plasma concentrations were measured by high-performance liquid chromatography assay with UV detector at 255-nm wavelength. Pharmacokinetic parameters were derived by use of a standard noncompartmental pharmacokinetic analysis. Samples from six piglets showed good plasma concentrations of ponazuril, which peaked at 5.83 +/- 0.94g/mL. Mean +/- SD area under the plasma concentration-time curve was 1383.42 +/- 363.26h/g/mL, and the elimination half-life was 135.28 +/- 19.03h. Plasma concentration of ponazuril peaked at 42h (range, 36-48h) after administration and gradually decreased but remained detectable for up to 33days. No adverse effects were observed during the study period. The results indicate that ponazuril was relatively well absorbed following a single dose, which makes ponazuril likely to be effective in swine.
- 出版日期2014-12
- 单位中国兽医药品监察所; 青岛农业大学
