Nitrosopersulfide (SSNO-) decomposes in the presence of sulfide, cyanide or glutathione to give HSNO/SNO-: consequences for the assumed role in cell signalling

作者：Wedmann Rudolf; Ivanovic Burmazovic Ivana; Filipovic Milos R

来源：Interface Focus, 2017, 7(2): 20160139.

DOI：10.1098/rsfs.2016.0139

<jats:p>
The emergence of hydrogen sulfide (H
<jats:sub>2</jats:sub>
S) as a new signalling molecule able to control vasodilation, neurotransmission and immune response, prompted questions about its possible cross-talk with the other gasontransmitter, nitric oxide (NO). It has been shown that H
<jats:sub>2</jats:sub>
S reacts with NO and its metabolites and several potentially biologically active species have been identified. Thionitrous acid (HSNO) was proposed to be an intermediate product of the reaction of
<jats:italic>S</jats:italic>
-nitrosothiols with H
<jats:sub>2</jats:sub>
S capable of crossing the membranes and causing further trans-nitrosation of proteins. Alternatively, formation of nitrosopersulfide (SSNO
<jats:sup>−</jats:sup>
) has been proposed in this reaction. SSNO
<jats:sup>−</jats:sup>
was claimed to be particularly stable and inert to H
<jats:sub>2</jats:sub>
S, thiols and cyanides. It is suggested that this putative SSNO
<jats:sup>−</jats:sup>
slowly decomposes to give NO, HNO and polysulfides. However, the chemical studies with pure SSNO
<jats:sup>−</jats:sup>
salts showed some conflicting observations. In this study, we work with pure PNP
<jats:sup>+</jats:sup>
SSNO
<jats:sup>−</jats:sup>
to show that contrary to everything that is claimed for the yellow reaction product of GSNO with H
<jats:sub>2</jats:sub>
S, pure SSNO
<jats:sup>−</jats:sup>
decomposes readily in the presence of cyanide, H
<jats:sub>2</jats:sub>
S and glutathione to form SNO
<jats:sup>−</jats:sup>
. Based on literature overview and chemical data about the structures of HSNO/SNO
<jats:sup>−</jats:sup>
and SSNO
<jats:sup>−</jats:sup>
we discuss the biological role these two species could have.
</jats:p>

• 出版日期2017-4-6